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QUINTERO RUIZ , María Cristina

Last name: QUINTERO RUIZ

First name: María Cristina

February 8, 2018 (v1)

Publication

Metadata-only

TDP2-Dependent Non-Homologous End-Joining Protects against Topoisomerase II-Induced DNA Breaks and Genome Instability in Cells and In Vivo

Gómez Herreros, Fernando Romero Granados, Rocío Zeng, Zhihong

Anticancer topoisomerase >poisons> exploit the break-and-rejoining mechanism of topoisomerase II (TOP2) to generate TOP2-linked DNA double-strand breaks (DSBs). This characteristic underlies the clinical efficacy of TOP2 poisons, but is also implicated in chromosomal translocations and genome instability associated with secondary,...

Uploaded on: March 27, 2023