RÉCHER , Christian

Last name: RÉCHER

First name: Christian

November 3, 2023 (v1)

Publication

Metadata-only

First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia

Salamero, Olga Montesinos, Pau Willekens, Christophe

PURPOSE Iadademstat is a novel, highly potent, and selective inhibitor of LSD1 (KDM1A), with preclinical in vitro and in vivo antileukemic activity. This study aimed to determine safety and tolerability of iadademstat as monotherapy in patients with relapsed/refractory acute myeloid leukemia (R/R AML). METHODS This phase I, nonrandomized,...

Uploaded on: November 25, 2023
November 29, 2018 (v1)

Journal article

Metadata-only

Interest of Dosing of Ibrutinib in B-Cell Lymphoid Malignancies: Data from a Real-Life, Phase 4 Study

Calleja, Anne de Barros, Sandra Vinson, Camille

International audience

Uploaded on: December 4, 2022
August 13, 2020 (v1)

Journal article

Metadata-only

Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites

Bosc, Claudie Broin, Nicolas Fanjul, Marjorie

Autophagy has been associated with oncogenesis with one of its emerging key functions being its contribution to the metabolism of tumors. Therefore, deciphering the mechanisms of how autophagy supports tumor cell metabolism is essential. Here, we demonstrate that the inhibition of autophagy induces an accumulation of lipid droplets (LD) due to...

Uploaded on: December 4, 2022

RÉCHER , Christian

Recent uploads