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Background - The goal of this study was to evaluate the antibody specificity of anti-HLA class I antibodies (Ab) detected in the sera of alloimmunized patients (Pts) waiting for a kidney retransplantation (AP-WKRTx). Methods - The study group consisted of 56 potential transplant recipients showing a panel reactive antibody values (PRA) >5%. Ab...

The pathogenesis of immunological and nonimmunological components that cause chronic kidney allograft nephropathy (CAN), is not yet completely understood. To explore the possible contribution of alloreactive cytotoxic T cells, we analyzed the transcription of cytotoxic molecules such as granzyme B and perforin using semiquantitative RT-PCR on...

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A longitudinal screening for JC polyomavirus (JCV) was performed in natalizumab-treated multiple sclerosis (MS) patients, immunocompromised patients and immunecompetent subjects to identify the incidence of JCV reactivation in these different groups. Thirty-eight MS patients were selected for natalizumab-treatment: 23 patients were treated for...