ROMANO , Paola

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In Antarctic sea waters the composition and structure of living communities and the morphology of species are strongly affected by low temperatures; furthermore, the environmental conditions and the adaptive strategies promoted evolution efforts and development of endemisms. Scanning electron microscopy can greatly contribute to the knowledge...

Scanning electron microscopy (SEM) can highly contribute to the knowledge of body structures in order to differentiate between different species or between varieties of the same species; this is important in extreme environments, such as in Antarctic waters, where the evolution efforts promoted the development of endemisms. In this work the...

Our complementary methods can represent an high content sensitive tool to assess the safety of chemical mixtures, that can act on skin, as well on eye and neural functions. Aim of this study was to assess the toxic potential of two mixtures (Cat. EWC160506, one inorganic and one organic), by different in vitro approaches.

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Molti dei composti immessi nell'ambiente dalle attività umane, capaci di indurre tossicità nei confronti delle cellule e degli organismi, sono sostanze di sintesi e, in quanto di origine "non naturale", vengono definiti "xenobiotici". Poiché l'uso di ogni nuovo composto sintetizzato deve essere approvato da parte di organi competenti in seguito...

2D- compared 3D- human cell models: cytotoxic effects of humid lightweight coal ash derived from the disposal of waste

Aim of this study was to verify the action, in rats in vivo, of the protein isoprenylation inhibitor perillyl alcohol (POH) and that of vitamin A, alone or in association, on m-RNA and protein expression of farnesyltransferases (FTases a and b subunits) and their protein substrates RhoA and RhoB, in isolated hepatocytes. Combined administration...

To identify non-animal tests for predicting human skin irritation, the European Centre for the Validation of Alternative Methods, ECVAM, promotes prevalidation studies focused on the evaluation of suitable in vitro assays. Epidermal differentiation requires the sequential regulation of specific genes, with their simultaneous activation and...

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