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RADETTI , Giorgio

Last name: RADETTI

First name: Giorgio

2016 (v1)

Publication

Metadata-only

Cut-off limits of the peak GH response to stimulation tests for the diagnosis of GH deficiency in children and adolescents: Study in patients with organic GHD

Guzzetti, Chiara Ibba, Anastasia Pilia, Sabrina

Objective: The diagnosis of GH deficiency (GHD) in children and adolescents is established when GH concentrations fail to reach an arbitrary cut-off level after at least two provocative tests. The objective of the study was to define the optimal GH cut-offs to provocative tests in children and adolescents. Design: Retrospective study in 372...

Uploaded on: April 14, 2023
2016 (v1)

Publication

Metadata-only

JAG1 loss-of-function variations as a novel predisposing event in the pathogenesis of congenital thyroid defects

De Filippis, Tiziana Marelli, Federica Nebbia, Gabriella

Context: The pathogenesis of congenital hypothyroidism (CH) is still largely unexplained. We previously reported that perturbations of the Notch pathway and knockdown of the ligand jagged1 cause a hypothyroid phenotype in the zebrafish. Heterozygous JAG1 variants are known to account for Alagille syndrome type 1 (ALGS1), a rare multisystemic...

Uploaded on: April 14, 2023