RADI M.

The synthetic strategies so far developed to build the pyrazolo[3,4-d]pyrimidine ring system and to generate highly functionalized analogs, with a particular emphasis on the 4-amino derivs., has been reviewed (75 refs.). The evolution of this versatile scaffold, starting from the pioneering work of Robins up to the recent prepn. of selective...

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The cytoplasmatic tyrosine in kinase c-Src is involved in the regulation of several cell functions including adhesion, invasion, proliferation, survival and angiogenesis. Src activity is strictly regulated in healthy cells, whereas its overexpression or hyperactivation plays a crit. role during tumor development. Recently it has been...