RAMPINELLI , Fabio

Background Programmed death 1 (PD-1) is an immunologic checkpoint that limits immune responses by delivering potent inhibitory signals to T cells on interaction with specific ligands expressed on tumor/virus-infected cells, thus contributing to immune escape mechanisms. Therapeutic PD-1 blockade has been shown to mediate tumor eradication with...

Background: PD-1 is an immunological checkpoint that limits immune responses by delivering potent in-hibitory signals to T cells upon interaction with specific ligands expressed on tumor/virus-infected cells, thus contributing to immune escape mechanisms (1). Therapeutic PD-1 blockade has been shown to medi-ate tumor eradication with impressive...

In this study the phenotype and function of tumor-associated NK cells from peritoneal fluids of a selected cohort of patients with seropapillary ovarian carcinoma were analyzed. In > 50% of these patients, the expression of the activating receptor NKp30 in tumor-associated NK cells was substantially reduced as compared to autologous peripheral...