Neovascular age-related macular degeneration (vAMD), characterized by the neo-vascularization of the retro-foveolar choroid, leads to blindness within few years. This disease depends on angiogenesis mediated by the vascular endothelial growth factor A (VEGF) and to inflammation. The only available treatments consist of monthly intravitreal...
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July 29, 2020 (v1)Journal articleUploaded on: October 14, 2023
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March 2023 (v1)Journal article
Two phenylspirodrimanes, never isolated before, stachybotrin J (1) and new stachybocin G (epi-stachybocin A) (2), along with the already reported stachybotrin I (3), stachybotrin H (4), stachybotrylactam (5), stachybotrylactam acetate (6), 2α-acetoxystachybotrylactam acetate (7), stachybotramide (8), chartarlactam B (9), and F1839-J (10) were...
Uploaded on: October 13, 2023 -
March 2023 (v1)Journal article
Two phenylspirodrimanes, never isolated before, stachybotrin J (1) and new stachybocin G (epi-stachybocin A) (2), along with the already reported stachybotrin I (3), stachybotrin H (4), stachybotrylactam (5), stachybotrylactam acetate (6), 2α-acetoxystachybotrylactam acetate (7), stachybotramide (8), chartarlactam B (9), and F1839-J (10) were...
Uploaded on: October 14, 2023 -
January 2022 (v1)Journal article
Objectives: To investigate the role of cancer-associated fibroblasts (CAFs) in clear cell renal cell carcinoma (ccRCC) with respect to tumour aggressiveness, metastasis development, and resistance to anti-angiogenic therapy (vascular endothelial growth factor receptor-tyrosine kinase inhibitors [VEGFR-TKI]).Patients and methods: Our study...
Uploaded on: December 3, 2022 -
January 1, 2020 (v1)Journal article
International audience
Uploaded on: October 14, 2023 -
September 21, 2021 (v1)Journal article
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Uploaded on: October 14, 2023 -
September 20, 2022 (v1)Journal article
Highlights d AXL and c-MET are overexpressed in radiotherapy-and cisplatin-resistant HNSCC d Overexpression of AXL and c-MET contributes to tumor aggressiveness and poor prognosis d Cabozantinib has anti-tumor and anti-metastatic efficacy in mice and zebrafish models d Cabozantinib efficacy is shown on HNSCC biopsies and in one patient after...
Uploaded on: October 14, 2023