RAZETTI , Agustina

How the brain wires up during development remains an open question in the scientific community across disciplines. Fruitful efforts have been made to elucidate the mechanisms of axonal growth, such as pathfinding and guiding molecules. However, recent evidence suggests other actors to be involved in neuron growth in vivo. Notably, axons develop...

In Drosophila brain, gamma neurons in the mushroom body are involved in higher functions such as olfactory learning and memory. During metamorphosis, they undergo remodelling after which they adopt their adult shape. Some mutations alter remodelling and therefore neuronal final morphology, causing behavioural dysfunctions. The RNA binding...

In order to reach their final adult morphology, Gamma neurons in Drosophila brain undergo a process of pruning followed by regrowth of their main axons and branches called remodelling. The mRNA binding protein Imp was identified to play a fundamental role in this process. One of Imp targets, profilin mRNA, encodes for an actin regulator that...

International audience

Neurite extension is essential to establish complex neuronal circuits during brain development. Neurons extend their axons in a crowded environment to reach target territories and connect to specific partners. Much work has been performed on cultured isolated neurons, focusing on the response of axon growing ends to chemical guidance cues....

Neurite extension is essential to establish complex neuronal circuits during brain development. In particular, neurons extend long cytoplasmic projections, the axons, in a crowded environment to reach target territories and connect to specific partners. Much work has been performed on cultured isolated neurons, focusing on the response of axon...

International audience