R

RE N.

Last name: RE N.

2012 (v1)

Publication

Metadata-only

Calcium binding promotes Prion Protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure

Sorrentino S. Bucciarelli T. CORSARO, ALESSANDRO

The pathological form of prion protein (PrPSc), as other amyloidogenic proteins, causes a marked increase of membrane permeability. PrPSc extracted from infected Syrian hamster brains induces a considerable change in membrane ionic conductance, although the contribution of this interaction to the molecular mechanism of neurodegeneration process...

Uploaded on: April 14, 2023