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RENNEVILLE , Aline

Last name: RENNEVILLE

First name: Aline

April 2012 (v1)

Journal article

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BCL2L10 is a predictive factor for resistance to Azacitidine in MDS and AML patients

Cluzeau, Thomas Robert, Guillaume Mounier, Nicolas

Azacitidine is the leading compound to treat patients suffering myelodysplastic syndrome (MDS) or AML with less than 30% of blasts, but a majority of patients is primary refractory or rapidly relapses under treatment. These patients have a drastically reduced life expectancy as compared to sensitive patients. Therefore identifying predictive...

Uploaded on: October 14, 2023
February 21, 2024 (v1)

Publication

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Targeting Heterochromatin Eliminates Malignant Hematopoietic Stem and Progenitor Cells in Chronic Myelomonocytic Leukemia Through Reactivation of Retroelements and Innate Immune pathways

Hidaoui, Donia Chelbie, Rabie Bohm, Mathieu

Abstract Chronic myelomonocytic leukemia (CMML) is a severe myeloid malignancy affecting the elderly, for which therapeutic options are limited. DNA hypomethylating agents (HMAs) provide transient responses, failing to eradicate the malignant clone. Hematopoietic stem cell (HSC) aging involves a reorganization of heterochromatin, evidenced by...

Uploaded on: February 23, 2024