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REPETTO , Ivan Enrico

Last name: REPETTO

First name: Ivan Enrico

2017 (v1)

Publication

Metadata-only

The Decrease of Uch-L1 Activity Is a Common Mechanism Responsible for Aβ 42 Accumulation in Alzheimer's and Vascular Disease

Guglielmotto, Michela Monteleone, Debora Vasciaveo, Valeria

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Uploaded on: April 14, 2023
2019 (v1)

Publication

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Stroke and Amyloid-β Downregulate TREM-2 and Uch-L1 Expression that Synergistically Promote the Inflammatory Response

Guglielmotto, Michela Repetto, Ivan Enrico Monteleone, Debora

Neuroinflammation is involved in the pathogenesis of Alzheimer's disease, and the transcription factor NF-κB is a player in this event. We found here that the ischemic damage alone or in association with Aβ1-42 activates the NF-κB pathway, induces an increase of BACE1 and a parallel inhibition of Uch-L1 and TREM2, both in vitro and in vivo, in...

Uploaded on: April 14, 2023