REVERCHON , E.

In this work, the supercritical assisted injection in a liquid antisolvent (SAILA) has been proposed as a new technique to produce composite microparticles for drug controlled release. Coprecipitation has been attempted for different non-steroidal anti-inflammatory drugs (Diclofenac, DF, Piroxicam, PX, and Indomethacin, ID) using...

Graphical abstract: Liposomes are natural vesicles generally based on phosphatidylcholine (PC). The optimization of the lipid bilayer composition with the addition of little percentages of natural lipids is still at early stage due to the difficulties experienced by classical liposome formation processes, mainly, in reproducibility and...

Liposomes are spherical vesicles made of a double layer of phospholipids and an inner water volume; these biocompatible drug carriers are used for the vehiculation of hydrophilic, amphiphilic or lipophilic compounds. Conventional methods for the production of liposomes are characterized by several drawbacks such as low encapsulation...

Conventional techniques developed for the production of liposomes for ocular delivery show low encapsulation efficiencies (EE). In this work, a supercritical CO2based one-step continuous process, named Supercritical Assisted Liposome formation (SuperLip), was used for the production of liposomes to deliver ophthalmic antibiotics, such as...

Sub-micronization of palmitoylethanolamide (PEA) was successfully performed using fast precipitation coupled with supercritical fluid extraction. Different solvents were tested: acetone, ethyl acetate, isopropanol, dimethyl sulfoxide and ethanol; water was used as the antisolvent. PEA precipitated in all cases as crystals of hexagonal...