REYES , J.l.

Newborn rat distal cells express an apical Ca 2+ channel activated by dihydropyridine drugs. Similarly, in Madin-Darby canine kidney (MDCK) cells, nifedipine increased Ca 2+ i in a concentration-dependent manner (IC 50 = 4 µM ) in fura-2-loaded cells. Response to nifedipine was abolished by EGTA, suggesting that it depends on extracellular...