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RIBEIRO , Barbara

Last name: RIBEIRO

First name: Barbara

September 28, 2020 (v1)

Journal article

Metadata-only

Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells

de Waard, Stephan Montnach, Jérôme Ribeiro, Barbara

IKr current, a major component of cardiac repolarization, is mediated by human Ether-à-go-go-Related Gene (hERG, Kv11.1) potassium channels. The blockage of these channels by pharmacological compounds is associated to drug-induced long QT syndrome (LQTS), which is a life-threatening disorder characterized by ventricular arrhythmias and defects...

Uploaded on: October 4, 2024