RICHEZ , Valentine

Nous avons rétrospectivement étudié le profil des infections bactériennes (BI) survenues au cours des phases de consolidations et d'intensification retardée (IR) du protocole GRAALL-2005, étude incluant des patients adultes atteints de LAL non Ph1. Les BI ont été définies par l'identification microbiologique de bactéries chez les patients en...

IPSS-R classifies cytogenetic abnormalities into five prognostic groups for survival. Monosomal karyotype (MK) is not a subgroup of IPSS-R. Additional prognostic information from MK in poor and very poor karyotype has been recently shown. The aim of our study was to determine the prognostic value of IPSS-R and MK for response and survival in...

International audience

Multiple myeloma (MM) evolves from a premalignant condition known as monoclonal gammopathy of undetermined significance (MGUS). However, the factors underlying the malignant transformation of plasmocytes in MM are not fully characterized. We report here that Eµ-directed expression of the antiapoptotic Bcl-B protein in mice drives an MM...