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RIGHETTI , Giada

Last name: RIGHETTI

First name: Giada

2022 (v1)

Publication

Metadata-only

Journey on VX-809-Based Hybrid Derivatives towards Drug-like F508del-CFTR Correctors: From Molecular Modeling to Chemical Synthesis and Biological Assays

Parodi, Alice Righetti, Giada Pesce, Emanuela

Cystic fibrosis (CF) is a genetic disease affecting the lungs and pancreas and causing progressive damage. CF is caused by mutations abolishing the function of CFTR, a protein whose role is chloride's mobilization in the epithelial cells of various organs. Recently a therapy focused on small molecules has been chosen as a main approach to...

Uploaded on: March 27, 2023