RIGOLLI , Nicola

All living organisms are surrounded by fluids, either air or water, which create unique sensory landscapes. For example, chemical signals disperse in the flow by diffusion and advection and when the flow is turbulent odor concentration breaks up in filaments and discrete patches of varying intensity. In my thesis I focused on olfactory...

Lipid distribution in the eukaryotic cells depends on tight couplings between lipid transfer and lipid metabolism. Yet these couplings remain poorly described. Notably, it is unclear to what extent lipid exchangers of the OSBP-related proteins (ORPs) family, coupled to PI(4)P metabolism, contribute to the formation of sterol and...

Oxysterol-binding protein-related proteins (ORPs) play key roles in the distribution of lipids in eukaryotic cells by exchanging sterol or phosphatidylserine for PI4P between the endoplasmic reticulum (ER) and other cell regions. However, it is unclear how their exchange capacity is coupled to PI4P metabolism. To address this question...