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RISSEL , Mary

Last name: RISSEL

First name: Mary

July 2008 (v1)

Journal article

Metadata-only

Regulation of Na+/H+ exchanger 1 allosteric balance by its localization in cholesterol- and caveolin-rich membrane microdomains.

Tekpli, Xavier Huc, Laurence Lacroix, Jérôme

The Na+/H+ exchanger 1, which plays an essential role in intracellular pH regulation in most tissues, is also known to be a key actor in both proliferative and apoptotic processes. Its activation by H+ is best described by the Monod-Wyman-Changeux model: the dimeric NHE-1 oscillates between a low and a high affinity conformation, the balance...

Uploaded on: December 4, 2022
December 23, 2008 (v1)

Journal article

Metadata-only

Kinetic analysis of the regulation of the Na+/H+ exchanger NHE-1 by osmotic shocks.

Lacroix, Jérôme Poët, Mallorie Huc, Laurence

NHE-1 is a ubiquitous, mitogen-activatable, mammalian Na+/H+ exchanger that maintains cytosolic pH and regulates cell volume. We have previously shown that the kinetics of NHE-1 positive cooperative activation by intracellular acidifications fit best with a Monod-Wyman-Changeux mechanism, in which a dimeric NHE-1 oscillates between a low- and a...

Uploaded on: December 4, 2022