RIVOLI G.

Background: Peripheral T-cell lymphomas (PTCL) represent a heterogeneous group of hematologic malignancies frequently presenting at advanced stage of diagnosis.Methods: We report a case of PTCL with an uncommon and aggressive onset with disseminated intravascular coagulation (DIC).Results: Laboratory findings revealed an aberrant expression of...

Purpose: Colistin is usually the only drug fully active against multi-drug resistant Gram-negative bacteria, but its nephrotoxicity might limit its use. Recent pharmacokinetic/pharmacodynamic data suggest that high dose of colistin, preceded by a loading dose, are needed to maximize its antibacterial effect. The aim of this study was to...

Metabolic reprogramming is emerging as a cancer vulnerability that could be therapeutically exploitable using different approaches, including amino acid depletion for those tumors that rely on exogenous amino acids for their maintenance. -Asparaginase (ASNase) has contributed to a significant improvement in acute lymphoblastic leukemia...