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Last name: ROCCHI
First name: Stéphane
International audience
International audience
International audience
Melanoma is the deadliest form of skin cancer. While associated survival prognosis is good when diagnosed early, it dramatically drops when melanoma progresses into its metastatic form. Prior to 2011, the favored therapies include interleukin-2 and chemotherapies, regardless of their low efficiency and their toxicity. Following key biological...
Abstract Amidinoureas are an understudied class of molecules with unique structural properties and biological activities. A simple methodology has been developed for the synthesis of aliphatic substituted amidinoureas via unexpected cycle opening of benzothiazolo‐1,3,5‐triazine‐2‐ones and transamination reaction of N ‐( N...
We recently described a new family of bioactive molecules with interesting anti-cancer activities: the N-(4-(3-aminophenyl)thiazol-2-yl)acetamides. The lead compound of the series (1) displays significant anti-proliferative and cytotoxic activities against a panel of cancer cell lines, either sensitive or resistant to standard treatments. This...
Four novel arylbiamidine series were studied showing particular tautomerism and H-bonding structure highlighting their promising druglike features toward anticancer applications.
Four novel arylbiamidine series were studied showing particular tautomerism and H-bonding structure highlighting their promising druglike features toward anticancer applications.
Four novel arylbiamidine series were studied showing particular tautomerism and H-bonding structure highlighting their promising druglike features toward anticancer applications.
Cancer is the second cause of deaths worldwide and is forecasted to affect more that 22 million people in 2020. Despite dramatic improvement in its care over the last two decades, the treatment of resistant forms of cancer is still an unmet challenge. Thus, innovative and efficient treatments are still needed. In this context, we report herein...
Several reports have demonstrated the inhibitory effect of metformin, a widely used drug in the treatment of type 2 diabetes, on the proliferation of many cancers including melanoma. Recently, it has been shown that metformin is able to modulate the cAMP level in the liver. As cAMP has a crucial role in melanin synthesis and skin pigmentation,...