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RODRÍGUEZ GOTOR , Juan J.

Last name: RODRÍGUEZ GOTOR

First name: Juan J.

November 28, 2022 (v1)

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Altered Cortical Palmitoylation Induces Widespread Molecular Disturbances in Parkinson's Disease

Cervilla-Martínez, Juan F. Rodríguez Gotor, Juan J. Wypijewski, Krzysztof J.

The relationship between Parkinson's disease (PD), the second-most common neurodegenerative disease after Alzheimer's disease, and palmitoylation, a post-translational lipid modification, is not well understood. In this study, to better understand the role of protein palmitoylation in PD and the pathways altered in this disease, we analyzed the...

Uploaded on: March 24, 2023
May 19, 2022 (v1)

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Increased novelty-induced locomotion, sensitivity to amphetamine, and extracellular dopamine in striatum of Zdhhc15-deficient mice

Mejías Estévez, Rebeca María Rodríguez Gotor, Juan J. Niwa, Minae

Novelty-seeking behaviors and impulsivity are personality traits associated with several psychiatric illnesses including attention deficits hyperactivity disorders. The underlying neural mechanisms remain poorly understood. We produced and characterized a line of knockout mice for zdhhc15, which encodes a neural palmitoyltransferase. Genetic...

Uploaded on: March 25, 2023