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RODRÍGUEZ-LOBATO , Luis G.

Last name: RODRÍGUEZ-LOBATO

First name: Luis G.

February 6, 2024 (v1)

Publication

Metadata-only

All-trans retinoic acid works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T cells

García-Guerrero, Estefanía Rodríguez-Lobato, Luis G. Sierro-Martínez, Belén

B-cell maturation antigen (BCMA) is the lead antigen for chimeric antigen receptor (CAR) T-cell therapy in multiple myeloma (MM). A challenge is inter- and intra-patient heterogeneity in BCMA expression on MM cells and BCMA downmodulation under therapeutic pressure. Accordingly, there is a desire to augment and sustain BCMA expression on MM...

Uploaded on: February 11, 2024