RODRIGUES , Giovanna Assis

Steroidogenic Factor-1 (SF-1/Ad4BP; NR5A1), a nuclear receptor transcription factor, has a pivotal role in adrenal and gonadal development in humans and mice. A frequent feature of childhood adrenocortical tumors (ACT) is SF-1 amplification and overexpression. Here we show that an increased SF-1 dosage can by itself augment human adrenocortical...