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RODRIGUES , Nuno

Last name: RODRIGUES

First name: Nuno

February 9, 2017 (v1)

Journal article

Metadata-only

Development of the First Two-Pore Domain Potassium Channel TWIK-Related K + Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity

Vivier, Delphine Soussia, Ismail Ben Rodrigues, Nuno

The TWIK-related K+ channel, TREK-1, has recently emerged as an attractive therapeutic target for the development of a novel class of analgesic drugs, suggesting that activation of TREK-1 could result in pain inhibition. Here, we report the synthesis of a series of substituted acrylic acids (1-54) based on our previous work with caffeate...

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