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ROMEO GUITART , David

Last name: ROMEO GUITART

First name: David

June 10, 2019 (v1)

Publication

Metadata-only

SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons

Romeo Guitart, David Leiva Rodríguez, Tatiana Espinosa Alcantud, María

Sirtuin 1 (SIRT1) activity is neuroprotective, and we have recently demonstrated its role in the retrograde degenerative process in motoneurons (MNs) in the spinal cord of rats after peripheral nerve root avulsion (RA) injury. SIRT2 has been suggested to exert effects opposite those of SIRT1; however, its roles in neurodegeneration and neuron...

Uploaded on: March 27, 2023