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ROMERO BARRAGÁN , M. Teresa

Last name: ROMERO BARRAGÁN

First name: M. Teresa

December 1, 2021 (v1)

Publication

Metadata-only

Selective expression of the neurexin substrate for presenilin in the adult forebrain causes deficits in associative memory and presynaptic plasticity

Sánchez Hidalgo, Ana Carmen Arias-Aragón, Francisco Romero Barragán, M. Teresa

Presenilins (PS) form the active subunit of the gamma-secretase complex, which mediates the proteolytic clearance of a broad variety of type-I plasma membrane proteins. Loss-of-function mutations in PSEN1/2 genes are the leading cause of familial Alzheimer's disease (fAD). However, the PS/gamma-secretase substrates relevant for the neuronal...

Uploaded on: December 4, 2022