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ROMERO REAL , V.

Last name: ROMERO REAL

First name: V.

February 5, 2024 (v1)

Publication

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Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors

Roldán Peña, Jesús Miguel Romero Real, V. Hicke, Javier

Concerned by the devastating effects of Alzheimer's disease, and the lack of effective drugs, we have carried out the design of a series of tacrine-phenolic heterodimers in order to tackle the multifactorial nature of the disease. Hybridization of both pharmacophores involved the modification of the nature (imino, amino, ether) and the length...

Uploaded on: February 7, 2024