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ROSE , Rebecca

Last name: ROSE

First name: Rebecca

March 9, 2020 (v1)

Publication

Metadata-only

Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum

Mejías Estévez, Rebeca María Chiu, Shu-Ling Rose, Rebecca

Cerebellar Purkinje cell (PC) loss is a consistent pathological finding in autism. However, neural mechanisms of PC-dysfunction in autism remain poorly characterized. Glutamate receptor interacting proteins 1/2 (Grip1/2) regulate AMPA receptor (AMPAR) trafficking and synaptic strength. To evaluate role of PC-AMPAR signaling in autism, we...

Uploaded on: December 4, 2022