ROSSBERG , André

Up until now, molecular chelating agents, such as the diethylenetriamine pentaacetic acid (DTPA) have been the standard method for actinide human decorporation. Mainly active in blood serum, their distribution within the body is thus limited. To treat a wider range of organs affected by plutonium contamination, a potential new class of...

The use of uranium and to a minor extent plutonium as fuel for nuclear energy production or as components in military applications is under increasing public pressure. Uranium is weakly radioactive in its natural isotopy but its chemical toxicity, combined with its large scale industrial utilization, makes it a source of concern in terms of...

The development of nuclear industries has raised multiple questions about its impact on the biotope and humans. Proteins are key biomolecules in cell machinery and essential actors in deciphering toxicological processes. Phosvitin was chosen as a relevant model for phosphorylated proteins and because of its important role as an iron, calcium,...

Since the 1940s, great amounts of Plutonium (Pu) have been produced for both military and civil purposes. Until now, the standard therapy for decorporation following inhalation has been the intravenous injection of diethylenetriaminepentaacetic acid ligand (Ca-DTPA form). This method offers a strong complexing constant for Pu(IV) but has poor...

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