ROSSOLINI , Gian Maria

Introduction: Klebsiella pneumoniae is a major agent of healthcare-associated infections and a cause of some community-acquired infections, including severe bacteremic infections associated with metastatic abscesses in liver and other organs. Clinical relevance is compounded by its outstanding propensity to evolve antibiotic resistance. In...

Introduction: Klebsiella pneumoniae is a major agent of healthcare-associated infections and a cause of some community-acquired infections, including severe bacteremic infections associated with metastatic abscesses in liver and other organs. Clinical relevance is compounded by its outstanding propensity to evolve antibiotic resistance. In...

In the last decades, there was an important paucity of agents for adequately treating infections due to metallo-beta-lactamases-producing Gram-negative bacteria (MBL-GNB). Cefiderocol, a novel siderophore cephalosporin showing in vitro activity against MBL-GNB, has been recently marketed, and a combination of aztreonam and ceftazidime/avibactam...

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The metabolites produced by the host's gut microbiota have an important role in the maintenance of intestinal homeostasis, but can also act as toxins and induce DNA damage in colorectal epithelial cells increasing the colorectal cancer (CRC) chance. In this scenario, the impact of some of the components of the natural human gastrointestinal...

Carbapenemase-producing Enterobacterales (CPE) represent a major cause of difficult-to-treat infections worldwide. The novel β-lactam/β-lactamase inhibitor combinations (BLICs), including ceftazidime/avibactam (CZA), meropenem/vaborbactam (MVB), and imipenem/relebactam (IMR), represented a breakthrough to treat some CPE infections. However,...

Objective: The main objectives were to describe two bla(KPC-2 ) plasmids recovered from Pseudomonas aeruginosa isolates belonging to the ST654 and ST235 high-risk clones, and to compare with complete sequences of bla(KPC-2 ) harbouring plasmids available in public databases.Methods: Antimicrobial susceptibility was determined according to CLSI...