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ROTHSTEIN , Rodney

Last name: ROTHSTEIN

First name: Rodney

February 9, 2018 (v1)

Publication

Metadata-only

Histone H3K56 Acetylation, Rad52, and Non-DNA Repair Factors Control Double-Strand Break Repair Choice with the Sister Chromatid

Muñoz Galván, Sandra Jimeno González, Sonia Rothstein, Rodney

DNA double-strand breaks (DSBs) are harmful lesions that arise mainly during replication. The choice of the sister chromatid as the preferential repair template is critical for genome integrity, but the mechanisms that guarantee this choice are unknown. Here we identify new genes with a specific role in assuring the sister chromatid as the...

Uploaded on: December 4, 2022
May 12, 2021 (v1)

Publication

Metadata-only

Impaired manganese metabolism causes mitotic misregulation

García Rodríguez, Néstor Díaz de la Loza, María del Carmen Andreson, Bethany

Manganese is an essential trace element, whose intracellular levels need to be carefully regulated. Mn2+ acts as a cofactor for many enzymes and excess of Mn2+ is toxic. Alterations in Mn2+ homeostasis affect metabolic functions and mutations in the human Mn2+/Ca2+ transporter ATP2C1 have been linked to Hailey-Hailey disease. By deletion of the...

Uploaded on: December 4, 2022