RUBIO CONTRERAS , Diana

Las lesiones que se producen en el ADN suponen un desafío continuo para la integridad genómica, siendo las roturas de doble cadena del ADN (DSBs) la lesión más citotóxica para la célula. Numerosos estudios han mostrado recientemente que una fuente fisiológica de DSBs es la actividad de las topoisomerasas de ADN, enzimas que eliminan el estrés...

DNA topoisomerase II (TOP2) is a major DNA metabolic enzyme, with important roles in replication, transcription, chromosome segregation and spatial organisation of the genome. TOP2 is the target of a class of anticancer drugs that poison the DNA-TOP2 transient complex to generate TOP2-linked DNA double-strand breaks (DSBs). The accumulation of...

Mesothelial cells form the mesothelium, a simple epithelium lining the walls of serous cavities and the surface of visceral organs. Although mesothelial cells are phenotypically well characterized, their immunoregulatory properties remain largely unknown, with only two studies reporting their capacity to inhibit T cells through TGF-β and their...