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RUGGERI , Loredana

Last name: RUGGERI

First name: Loredana

2023 (v1)

Publication

Metadata-only

Donor selection for adoptive immunotherapy with NK cells in AML patients: Comparison between analysis of lytic NK cell clones and phenotypical identification of alloreactive NK cell repertoire

Meazza, Raffaella Ruggeri, Loredana Guolo, Fabio

Natural killer (NK) cell-based adoptive immunotherapy in leukemia patients is an emerging field of interest based on clinical evidence of efficacy and safety. Elderly acute myeloid leukemia (AML) patients have been successfully treated with NK cells from HLA-haploidentical donors, especially when high amounts of alloreactive NK cells were...

Uploaded on: February 4, 2024
2016 (v1)

Publication

Metadata-only

Larger size of donor alloreactive NK cell repertoire correlates with better response to NK cell immunotherapy in elderly acute myeloid leukemia patients

Curti, Antonio Ruggeri, Loredana Parisi, Sarah

Purpose: In acute myeloid leukemia (AML), alloreactive natural killer (NK) cells are crucial mediators of immune responses after haploidentical stem cell transplantation. Allogeneic NK cell infusions have been adoptively transferred with promising clinical results. We aimed at determining whether the composition of NK graft in terms of...

Uploaded on: March 27, 2023