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RUSMINI , Paola

Last name: RUSMINI

First name: Paola

2022 (v1)

Publication

Metadata-only

Neurodegenerative Disease-Associated TDP-43 Fragments Are Extracellularly Secreted with CASA Complex Proteins

Casarotto, Elena Sproviero, Daisy Corridori, Eleonora

Extracellular vesicles (EVs) play a central role in neurodegenerative diseases (NDs) since they may either spread the pathology or contribute to the intracellular protein quality control (PQC) system for the cellular clearance of NDs-associated proteins. Here, we investigated the crosstalk between large (LVs) and small (SVs) EVs and PQC in the...

Uploaded on: April 14, 2023
2022 (v1)

Publication

Metadata-only

Pathogenic variants of Valosin Containing Protein induce lysosomal damage and transcriptional activation of autophagy regulators in neuronal cells

Ferrari, Veronica Cristofani, Riccardo Cicardi, Maria E

Aim: Mutations in the Valosin-containing protein (VCP) gene cause various lethal proteinopathies that mainly include inclusion body myopathy with Paget's disease of bone frontotemporal dementia (IBMPFD) and amyotrophic lateral sclerosis (ALS). Different pathological mechanisms have been proposed. Here, we define the impact of VCP mutants on...

Uploaded on: April 14, 2023