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RUSSO , Claudio

Last name: RUSSO

First name: Claudio

2019 (v1)

Publication

Metadata-only

Proteases Upregulation in Sporadic Alzheimer's Disease Brain

Medoro, Alessandro Bartollino, Silvia Mignogna, Donatella

Certain proteases are involved in Alzheimer's disease (AD) and their erroneous control may contribute to the pathology onset and progression. In this study we evaluated the cerebral expression of eight proteases, involved in both AβPP processing and extracellular matrix remodeling. Among these proteases, ADAM10, ADAMTS1, Cathepsin D, and Meprin...

Uploaded on: April 14, 2023
2018 (v1)

Publication

Metadata-only

Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death

Thellung, Stefano Scoti, Beatrice Corsaro, Alessandro

According to the "gain-of-toxicity mechanism", neuronal loss during cerebral proteinopathies is caused by accumulation of aggregation-prone conformers of misfolded cellular proteins, although it is still debated which aggregation state actually corresponds to the neurotoxic entity. Autophagy, originally described as a variant of programmed cell...

Uploaded on: March 27, 2023