SÁNCHEZ ALCÁZAR , José Antonio

Fibromyalgia (FM) is a common chronic pain syndrome accompanied by a myriad of variable physical and psychopathological symptoms such as fatigue, muscle stiffness, sleep disorders, morning tiredness, cognitive complaints, as well as depression and anxiety 1. Despite the fact that it affects up to 5% of the general population worldwide, its...

Composición para el tratamiento de enfermedades asociadas a trastornos lisosomales.Composición farmacéutica que comprende una chaperona farmacológica (CF) y Coenzima Q10 (CoQ) y su uso para el tratamiento de una enfermedad causada por mutaciones en el gen

Silver nanoparticles offer a huge potential for biomedical applications owing to their exceptional properties and small size. Specifically, cysteamine-capped silver nanoparticles could form the basis for new anticancer therapies combining the cytotoxic effect of the silver core with the inherent antitumor activity of cysteamine, which...

Background: Fibromyalgia (FM) is a chronic pain syndrome with unknown etiology and a wide spectrum of symptoms such as allodynia, debilitating fatigue, joint stiffness and migraine. Recent studies have shown some evidences demonstrating that oxidative stress is associated to clinical symptoms in FM of fibromyalgia. We examined oxidative stress...

Junta de Andalucía FQM-6615, PI0070, FQM319

Embryopathies that develop as a consequence of maternal diabetes have been studied intensely in both experimental and clinical scenarios. Accordingly, hyperglycaemia has been shown to downregulate the expression of elements in the non-canonical Wnt-PCP pathway, such as the Dishevelled-associated activator of morphogenesis 1 (Daam1) and Vangl2....

Objetivo: La fibromialgia es un síndrome de dolor crónico generalizado de etiología desconocida, que afecta predominantemente a mujeres. Dentro de las hipótesis que se han descrito como posibles mecanismos etiopatogénicos destaca la alteración de los valores y metabolismo de la serotonina y su relación con los síntomas en la fibromialgia. El...

Background: We examined lipid peroxidation (LPO) in blood mononuclear cells (BMCs) and plasma, as a marker of oxidative damage, and its association to clinical symptoms in Fibromyalgia (FM) patients. Methods: We conducted a case–control and correlational study comparing 65 patients and 45 healthy controls. Clinical parameters were evaluated...

Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Both mitochondrial dysfunction and inflammation have been implicated in the pathophysiology of FM. We have investigated the possible relationship between mitochondrial dysfunction, oxidative stress, and inflammation in FM. We studied 30 women...