SÁNCHEZ CÉSPEDES , Javier

The repositioning of drugs already approved by regulatory agencies for other indications is an emerging alternative for the development of new antimicrobial therapies. The repositioning process involves lower risks and costs than the de novo development of novel antimicrobial drugs. Currently, infections by adenovirus show a steady increment...

Motivación: La incidencia de infecciones por adenovirus (HAdV) en pacientes receptores de órgano sólido y especialmente de receptores de progenitores hematopoyéticos, ha aumentado en los últimos años, presentando una elevada morbi- mortalidad (1, 2). Actualmente no existen tratamientos específicos para este tipo de infecciones. Nuestro objetivo...

Based on imipenem resistance in an Acinetobacter genospecies 3 clinical isolate, we were able to identify, for the first time in this genomic species, a plasmid-encoded blaOXA-58 gene that was 100% homologous to the same gene in Acinetobacter baumannii.

Human adenoviruses (HAdVs) display a wide range of tissue tropism and can cause an array of symptoms from mild respiratory illnesses to disseminated and life-threatening infections in immunocompromised individuals. However, no antiviral drug has been approved specifically for the treatment of HAdV infections. Herein, we report our continued...

Cytomegalovirus (CMV) infection remains a significant challenge in solid organ transplantation (SOT). The last international consensus guidelines on the management of CMV in SOT were published in 2018, highlighting the need for revision to incorporate recent advances, notably in cell-mediated immunity monitoring, which could alter the current...

The aim was to analyze the characteristics and predictors of unfavorable outcomes in solid organ transplant recipients (SOTRs) with COVID-19. We conducted a prospective observa tional cohort study of 210 consecutive SOTRs hospitalized with COVID-19 in 12 Spanish centers from 21 February to 6 May 2020. Data pertaining to demographics, chronic...

Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-α2 alone (five patients) or with IFN-ω (eight patients) from a cohort of 279 patients (4.7%) aged 6–73 yr with critical influenza pneumonia. Nine...

Motivación: El adenovirus humano (HAdV) es un virus que causa infecciones autolimitadas y leves en individuos inmunocompetentes, en cambio, en pacientes inmunodeprimidos las infecciones suelen ser de caracter grave, presentando elevada morbilidad y mortalidad. En la actualidad no existe un antiviral específico para tratar...

The main objective was to evaluate the viability of the SARS-CoV-2 viral particles excreted in stools. In addition, we aimed to identify clinical factors associated with the detection of SARS-CoV-2 RNA in feces, and to determine if its presence is associated with an unfavorable clinical outcome, defned as intensive care unit (ICU) admission...

Nowadays there is not an effective drug for the treatment of infections caused by human adenovirus (HAdV) which supposes a clinical challenge, especially for paediatric and immunosuppressed patients. Here, we describe the design, synthesis and biological evaluation as anti-adenovirus agents of a new library (57 compounds) of diester, monoester...

Human adenovirus (HAdV) can produce disseminated disease with high mortality in pediatric allogenic hematopoietic stem cell transplant (allo-HSCT) recipients. In adult recipients, prospective studies addressing the incidence of HAdV infection and disease are lacking. The aim of this study was to characterize the kinetics of HAdV replication,...