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SÁNCHEZ PALAZÓN , Luis

Last name: SÁNCHEZ PALAZÓN

First name: Luis

January 28, 2019 (v1)

Publication

Metadata-only

Derivation of HVR1, HVR2 and HVR3 human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis (PGD) for monogenic disorder

Hmadcha, Abdelkrim Aguilera, Yolanda Lozano Arana, María Dolores

From 106 human blastocyts donate for research after in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD) for monogenetic disorder, 3 human embryonic stem cells (hESCs) HVR1, HVR2 and HVR3 were successfully derived. HVR1 was assumed to be genetically normal, HVR2 carrying Becker muscular dystrophy and HVR3 Hemophilia B....

Uploaded on: March 27, 2023
May 28, 2018 (v1)

Publication

Metadata-only

LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus

Cobo Vuilleumier, Nadia Lorenzo, Petra I. García Rodríguez, Noelia

Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune attack or stimulating beta cell regeneration still have limited clinical efficacy. Therefore, it is timely to identify innovative targets to dampen the immune process, while promoting...

Uploaded on: December 4, 2022