SÁNCHEZ-ALCAZAR , José Antonio

Aging is characterized by a progressive loss of physiological integrity, leading to the impairment of numerous functions and increased vulnerability to death. This deterioration is the primary risk factor for aging‐related major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases 1. Several...

Tannic acid (TA) has multiple effects against cancer, being especially promising in those types that overexpress the epidermal growth factor receptor (EGFR), as TA modulates its activation and downstream signaling pathways, triggering apoptosis. Nonetheless, despite the important role of this receptor in the pathogenesis and progression of a...

Amphiphilic glycomimetics encompassing a rigid, undistortable nor-tropane skeleton based on 1,6-anhydro-L-idonojirimycin and a polyfluorinated antenna, when formulated as the corresponding inclusion complexes with β-cyclodextrin (βCD), have been shown to behave as pharmacological chaperones (PCs) that efficiently rescue lysosomal β-...