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SØRENSEN , Poul

Last name: SØRENSEN

First name: Poul

March 20, 2017 (v1)

Journal article

Metadata-only

Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation

Andrio, Emilie Lotte, Romain Hamaoui, Daniel

The E3 ubiquitin ligase HACE1 is a potent tumor suppressor that controls cell proliferation and ubiquitylates the small GTPase Rac1 to target it to proteasomal degradation. Whether and how the activity of HACE1 is regulated by the N-terminal ankyrin (ANK) and the middle (MID) domains is ill defined. Here, we identified in the version 64 of the...

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