S. FILETTI

There is no effective treatment for recurrent or metastatic medullary thyroid carcinoma (MTC), a tumor arising from thyroid C-cells commonly presenting an inherited or acquired RET mutation. In this study we examined the sensitivity of two human MTC cell lines to novel pyrazolopyrimidine derivates, able to inhibit src-family tyrosine kinase...

In this study, we evaluated the activity of two novel pyrazolopyrimidine derivs. (Si 34 and Si 35) against ARO cells, a human anaplastic thyroid cancer cell line. ARO cells exposed to different concns. of the drugs showed a reduced growth rate and an increase of mortality. After 72 h incubation, doses of 5 and 10 μM Si 34 detd. a decrease of...