SOLDANO , Stefano

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Patients with systemic sclerosis show a decreased fingertip blood perfusion (FBP) partially reversible by local skin heating. The FBP correlates negatively with the extent of nailfold microvascular damage, and IV iloprost treatment increases the FBP.

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To investigate the effects of 17beta-estradiol (E2) on extracellular matrix (ECM) protein synthesis (collagen type I, fibronectin, and laminin) using cultures of normal and scleroderma (SSc) skin fibroblasts. Primary fibroblasts cultures, obtained from skin biopsies of six female voluntary subjects and three female SSc patients, were treated...

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Background: Systemic sclerosis (SSc) is characterized by early vascular abnormalities and subsequent fibroblast activation to myofibroblasts, leading to fibrosis. Recently, endothelial-to-mesenchymal transition (EndoMT), a complex biological process in which endothelial cells lose their specific markers and acquire a mesenchymal...

Previous studies have reported the presence of CD86 (B7.2) costimulatory molecule on endothelial cells (ECs) and recent data have shown that CTLA4-Ig (abatacept), used as a biological agent in rheumatoid arthritis, interacts with CD86 expressed on different cells involved in synovitis. Therefore, the effects of CTLA4-Ig/CD86 interaction on...

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To investigate the effects of the endothelin 1 (ET-1) receptor antagonists (ETRA) macitentan, its active metabolite ACT-132577, and bosentan on myofibroblast activation and extracellular matrix production induced by ET-1 in cultured systemic sclerosis (SSc) and control skin fibroblasts.

Rheumatoid arthritis (RA) prevalence is greater in females than in males, supporting estrogens as modulators of immune response. Leflunomide (LEF) is employed in the RA treatment. We studied the combinatory effects of LEF active metabolite A77 1726 (LEF-M) and 17beta-estradiol (E2) on inflammatory cytokine production by cultured macrophages...

The results suggest that the combination of prednisone and leflunomide seems to play a synergistic effect by modulating some inflammatory genes in early rheumatoid arthritis.

Clinical and experimental evidence indicates that rheumatoid arthritis prevalence is greater in females than in males, and supports a role for estrogens as modulators of the immune response. Immunocytochemistry (ICC) showed that the antiproliferative drug Leflunomide (LEF) is successfully employed in rheumatoid arthritis. In this study we...