S

SORDAT B.

Last name: SORDAT B.

2009 (v1)

Publication

Metadata-only

Catastrophic NAD(+) Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE

BRUZZONE, SANTINA FRUSCIONE, FLORIANA MORANDO, SARA

Nicotinamide phosphoribosyltransferase (Nampt) inhibitors such as FK866 are potent inhibitors of NAD(+) synthesis that show promise for the treatment of different forms of cancer. Based on Nampt upregulation in activated T lymphocytes and on preliminary reports of lymphopenia in FK866 treated patients, we have investigated FK866 for its...

Uploaded on: October 11, 2023