STIFANESE , Roberto

L'autore Denise R. Ferrier insegna presso il dipartimento di Biochimica e Biologia molecolare del Drexel University College of Medicine, Philadelphia. L'opera Le basi della biochimica presenta un profilo compatto della materia in grado di agevolare lo studente nell'apprendimento e nel superamento dell'esame. Tutti gli argomenti essenziali...

A calorimetric study of the RNi2 Laves phases (R = Pr, Nd, Sm, Gd, Tb, Dy, Ho and Er) has been carried out to determine the heat of formation (DfH) at 300 K using a high temperature direct drop calorimeter. The reliability of the calorimetric results has been determined and supported by using different analytical techniques: light optical...

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Necrosis of the NAC is a condition that penalizes patients who underwent breast reduction surgery or mastopexy. Breast reduction is a widely used technique for over-sized breasts. Breast hypertrophy, in fact, can cause the onset of many issues - both aesthetical and pathological - because of the excessive weight that the breasts exert on the...

Human circulating PBMC (peripheral blood mononuclear cells) contain three calpain isoforms distinguishable on the basis of their Chromatographic properties. Two of these proteases belong to the ubiquitous calpain subfamily, corresponding to the classical μ-and m-calpain forms. The third, which shows peculiar activating and regulatory...

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Ca2+ loading of Jurkat and bovine aorta endothelium cells induces the degradation of the neuronal and endothelial nitric oxide synthases that are selectively expressed in these cell lines. For neuronal nitric oxide synthase, this process involves a conservative limited proteolysis without appreciable loss of catalytic activity. By contrast,...

We are here reporting that calpain-1 is a constitutive component of a distinct lipid raft/caveolin-1 microdomain isolated from bEnd5 cells in association with endothelial nitric oxide synthase (eNOS) and heat shock protein 90 (HSP90). Perturbations in intracellular calcium concentration by Ca2+-ionophore A23187 or prolonged cell exposure to...

In resting human neuronal cells, nitric oxide synthase (nNOS) is present in its native 160 kDa form in a quiescent state predominantly co-localized on the plasma membrane, via its PDZ (Psd-95/Discs-large/Zona Occludens) domain, with NMDA receptor (NMDA-R) and in tight association with heat shock protein 90 (HSP90). Following exposure of the...

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It is generally accepted that the Ca2-dependent interaction of calpain with calpastatin is the most relevant mechanism involved in the regulation of Ca2-induced proteolysis.Wenow report that a calpain-calpastatin association can occur also in the absence of Ca2 or at very low Ca2 concentrations, reflecting the physiological conditions under...

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