SAFIR FILHO , Mauro

Interdisciplinary is an obvious feature of scientific research. Notably, the continuously expanding researches in the medical field fostered this interdisciplinarity. Within this context, the work presented here deals with fluorescence spectroscopy and nucleic acid chemistry and aims at providing new tools suited for applications in life...

We report the synthesis of two new artificial nucleobase scaffolds, 1 and 2, featuring adequate hydrogen bonding donors and acceptors for the molecular recognition of U:A and C:G base pairs, respectively. The tethering of these structures to various amino acids and the assessment of these artificial nucleobase-amino acid conjugates as RNA...

International audience

Selective imaging of cellular organelles is a rapidly expanding field of research. Within this context we describe the development of two novel profluorescent probes, MitoP-2 and MitoP-3, for the precise staining of mitochondrial compartments. Herein, we demonstrate that caged, non-fluorescent styryl-benzothiazole probes harbouring a...

A simple and eco-friendly route to gold – NHC complexes bearing different thiosugars is reported.

This study describes the synthesis, photophysical characterization, and TD-DFT calculation of a series of benzothiazole-based styryl fluorophores (F1-F5) harboring a D-π-A structure. The compounds were obtained through a simple and efficient synthetic route using low-cost starting materials. The investigation and analysis of their photophysical...