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SAINTAMAND , Alexis

Last name: SAINTAMAND

First name: Alexis

December 2017 (v1)

Journal article

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Eμ and 3'RR IgH enhancers show hierarchic unilateral dependence in mature B-cells

Saintamand, Alexis Vincent-Fabert, Christelle Marquet, Marie

Enhancer and super-enhancers are master regulators of cell fate. While they act at long-distances on adjacent genes, it is unclear whether they also act on one another. The immunoglobulin heavy chain (IgH) locus is unique in carrying two super-enhancers at both ends of the constant gene cluster: the 5'Eμ super-enhancer promotes VDJ...

Uploaded on: December 4, 2022
February 17, 2016 (v1)

Journal article

Metadata-only

Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region

Saintamand, Alexis Vincent-Fabert, Christelle Garot, Armand

The IgH 3' regulatory region (3'RR) controls class switch recombination (CSR) and somatic hypermutation (SHM) in B cells. The mouse 3'RR contains four enhancer elements with hs1,2 flanked by inverted repeated sequences and the centre of a 25-kb palindrome bounded by two hs3 enhancer inverted copies (hs3a and hs3b). hs4 lies downstream of the...

Uploaded on: February 28, 2023
February 9, 2016 (v1)

Journal article

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Sequential activation and distinct functions for distal and proximal modules within the IgH 3′ regulatory region

Garot, Armand Marquet, Marie Saintamand, Alexis

International audience

Uploaded on: December 4, 2022