SALES SANTA CRUZ , Guilherme

Prioritizing genes for their role in drug sensitivity, is an important step in understanding drugs mechanisms of action and discovering new molecular targets for co-treatment. To formalize this problem, we consider two sets of genes X and P respectively composing the gene signature of cell sensitivity at the drug IC 50 and the genes involved in...

Prioritizing genes for their role in drug sensitivity, is an important step in understanding drugs mechanisms of action and discovering new molecular targets for co-treatment. To formalize this problem, we consider two sets of genes X and P respectively composing the gene signature of cell sensitivity at the drug IC 50 and the genes involved in...

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Prioritizing genes for their role in drug sensitivity, is an important step in understanding drugs mechanisms of action and discovering new molecular targets for co-treatment. To formalize this problem, we consider two sets of genes X and P respectively composing the gene signature of cell sensitivity at the drug IC 50 and the genes involved in...

A central problem in the multi-omics era is to bridge the gap between genes/proteins of heterogeneous expression (call them sources) and proteins already known to be involved in a specific cell response signalling pathway (call them targets). Insights on this problem are of special interest to unveil the molecular basis of individual cell...