SANCHEZ , Clara

Obesity is a major public health problem, associated with "low-grade" systemic inflammation. Numerous studies have been devoted to understand the mechanisms behind obesity, and some of them have shown that deregulation in the brain may be responsible of it. In addition to peripheral inflammation, local hypothalamic inflammation has been found...

Abstract: Since being described in Drosophila melanogaster in 2011, the Smurf phenotype, has been seen to be evolutionarily conserved in nematode and zebrafish, and has helped to identify the discontinuous nature of ageing and predict impending death from natural causes as well as from environmental stresses. This phenotype allowed us to model...

Abstract Lipid-rich diet is the major cause of obesity, affecting 13% of the worldwide adult population. Obesity is a major risk factor for metabolic syndrome that includes hyperlipidemia and diabetes mellitus. The early phases of metabolic syndrome are often associated with hyperexcitability of peripheral small diameter sensory fibers and...