Natural quantitative variation in developmental processes, such as cell proliferation, must be driven by allelic variation. Yet, the genotype-phenotype relationships underlying such trait variation are understudied due to their inherent complexity. Taking advantage of the simple Caenorhabditis elegans germline stem cell system, we used a...
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November 7, 2022 (v1)PublicationUploaded on: December 4, 2022
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May 17, 2023 (v1)Journal article
Abstract To study how natural allelic variation explains quantitative developmental system variation, we characterized natural differences in germ stem cell niche activity, measured as progenitor zone (PZ) size, between two Caenorhabditis elegans isolates. Linkage mapping yielded candidate loci on chromosomes II and V, and we found that the...
Uploaded on: October 24, 2024 -
March 12, 2023 (v1)Journal article
ABSTRACT Evolutionary transitions from oviparity to viviparity are frequent across diverse taxa. Some species also display intraspecific variation in parity mode, or they exhibit an intermediate mode by laying eggs containing embryos at variable, often advanced stages of development. How such natural quantitative variation in egg retention...
Uploaded on: November 25, 2023 -
April 2, 2024 (v1)Journal article
Evolutionary transitions from egg laying (oviparity) to live birth (viviparity) are common across various taxa. Many species also exhibit genetic variation in egg-laying mode or display an intermediate mode with laid eggs containing embryos at various stages of development. Understanding the mechanistic basis and fitness consequences of such...
Uploaded on: October 22, 2024